Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial

Repurposing Probenecid for the Treatment of Heart Failure (Re-Prosper-HF): a study protocol for a randomized placebo-controlled clinical trial

Abstract Background Improving contractility in heart failure with reduced ejection fraction (HFrEF) has resurfaced as a potential treatment goal. Inotropic therapy is now better understood through its underlying mechanism as opposed to the observed effect of increasing contractility. Calcitropes are...

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Bibliographic Details
Main Authors: Jack Rubinstein, Nathan Robbins, Karen Evans, Gabrielle Foster, Kevin Mcconeghy, Toluwalope Onadeko, Julie Bunke, Melanie Parent, Xi Luo, Jacob Joseph, Wen-Chih Wu
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Trials
Subjects:
Probenecid
Heart failure
Contractility
Inotropy
Online Access:https://doi.org/10.1186/s13063-022-06214-y

Internet

https://doi.org/10.1186/s13063-022-06214-y

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