Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation

Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation

Abstract Background Kaixin Jieyu Granule (KJG), an improved formula of Kai-xin-san and Si-ni-san, is a highly effective formula with demonstrated efficacy in preventing depression in previous studies. However, the underlying molecular mechanisms of KJG’s antidepressant effects on inflammatory molecu...

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Bibliographic Details
Main Authors: Manman Xu, Wujianwen Zhai, Ying Zhang, Juhua Pan, Jie Li, Shijing Huang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Kaixin Jieyu Granule
Depression
Network pharmacology
Traditional chinese medicine
Neuroinflammation
Online Access:https://doi.org/10.1186/s12906-023-03970-5

Internet

https://doi.org/10.1186/s12906-023-03970-5

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