Limits of Chromosome Compaction by Loop-Extruding Motors
During mitosis, human chromosomes are linearly compacted about 1000-fold by loop-extruding motors. Recent experiments have shown that condensins extrude DNA loops but in a “one-sided” manner. This contrasts with existing models, which predict that symmetric, “two-sided” loop extrusion accounts for m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2019-07-01
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| Series: | Physical Review X |
| Online Access: | http://doi.org/10.1103/PhysRevX.9.031007 |