A multifaceted review of temozolomide resistance mechanisms in glioblastoma beyond O-6-methylguanine-DNA methyltransferase

A multifaceted review of temozolomide resistance mechanisms in glioblastoma beyond O-6-methylguanine-DNA methyltransferase

Temozolomide (TMZ), an oral alkylating agent, is a cornerstone of standard-of-care multimodality therapy for glioblastoma. In spite of significant efforts to treat this disease, the tumor carries a poor prognosis and is considered incurable largely due to the development of chemoresistance. One of t...

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Bibliographic Details
Main Authors: Peter Y. M. Woo, Yi Li, Anna H. Y. Chan, Stephanie C. P. Ng, Herbert H. F. Loong, Danny T. M. Chan, George K. C. Wong, Wai-Sang Poon
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Glioma
Subjects:
Glioblastoma
glioma stem cells
histone modification
microRNA
O-6-methylguanine-DNA methyltransferase
receptor tyrosine kinase
resistance
temozolomide
Online Access:http://www.jglioma.com/article.asp?issn=2589-6113;year=2019;volume=2;issue=2;spage=68;epage=82;aulast=Woo

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http://www.jglioma.com/article.asp?issn=2589-6113;year=2019;volume=2;issue=2;spage=68;epage=82;aulast=Woo

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