Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides

A series of N-alkyl-3-(alkylamino)pyrazine-2-carboxamides and their N-alkyl-3-chloropyrazine-2-carboxamide precursors were prepared. All compounds were characterized by analytical methods and tested for antimicrobial and antiviral activity. The antimycobacterial MIC values against Mycobacterium tube...

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Bibliographic Details
Main Authors: Lucia Semelkova, Klara Konecna, Pavla Paterova, Vladimir Kubicek, Jiri Kunes, Lucie Novakova, Jan Marek, Lieve Naesens, Matus Pesko, Katarina Kralova, Martin Dolezal, Jan Zitko
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
pyrazinamide
pyrazine
alkylation
aminodehalogenation
antimycobacterial activity
inhibition of photosynthetic electron transport
structure-activity relationships
Online Access:http://www.mdpi.com/1420-3049/20/5/8687

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http://www.mdpi.com/1420-3049/20/5/8687

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