Effects of siRNA on RET/PTC3 junction oncogene in papillary thyroid carcinoma: from molecular and cellular studies to preclinical investigations.

Effects of siRNA on RET/PTC3 junction oncogene in papillary thyroid carcinoma: from molecular and cellular studies to preclinical investigations.

RET/PTC3 junction oncogene is typical of radiation-induced childhood papillary thyroid carcinoma (PTC) with a short latency period. Since, RET/PTC3 is only present in the tumour cells, thus represents an interesting target for specific therapy by small interfering RNA (siRNA). Our aim is to demonstr...

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Bibliographic Details
Main Authors: Hafiz Muhammad Ali, Giorgia Urbinati, Hubert Chapuis, Didier Desmaele, Jean-Rémi Bertrand, Patrick Couvreur, Liliane Massaad-Massade
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3997558?pdf=render

Internet

http://europepmc.org/articles/PMC3997558?pdf=render

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