Photomechanical wave-driven delivery of siRNAs targeting intermediate filament proteins promotes functional recovery after spinal cord injury in rats.

Photomechanical wave-driven delivery of siRNAs targeting intermediate filament proteins promotes functional recovery after spinal cord injury in rats.

The formation of glial scars after spinal cord injury (SCI) is one of the factors inhibiting axonal regeneration. Glial scars are mainly composed of reactive astrocytes overexpressing intermediate filament (IF) proteins such as glial fibrillary acidic protein (GFAP) and vimentin. In the current stud...

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Bibliographic Details
Main Authors: Takahiro Ando, Shunichi Sato, Terushige Toyooka, Hiroaki Kobayashi, Hiroshi Nawashiro, Hiroshi Ashida, Minoru Obara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3522723?pdf=render

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http://europepmc.org/articles/PMC3522723?pdf=render

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