Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae

Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae

Abstract Background During the early stages of Trichinella spiralis infection, macrophages predominantly undergo polarization to the M1-like phenotype, causing the host’s inflammatory response and resistance against T. spiralis infection. As the disease progresses, the number of M2-type macrophages...

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Bibliographic Details
Main Authors: Ruo Dan Liu, Xiang Yu Meng, Chen Le Li, Qiu Yi Xu, Xin Zhi Lin, Bo Rang Dong, Chu Yan Ye, Tian Tian Miao, Xin Yi Si, Shao Rong Long, Jing Cui, Zhong Quan Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Parasites & Vectors
Subjects:
Trichinella spiralis
Cathepsin L
Macrophage polarization
NF-κB signaling pathway
ADCC
Online Access:https://doi.org/10.1186/s13071-023-06051-1

Internet

https://doi.org/10.1186/s13071-023-06051-1

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