Ghrelin cell–expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin

Ghrelin cell–expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin

Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell–selective insulin receptor–KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell–expressed insulin receptors (IRs), to suppress ghrelin secre...

Full description

Bibliographic Details
Main Authors: Kripa Shankar, Shota Takemi, Deepali Gupta, Salil Varshney, Bharath K. Mani, Sherri Osborne-Lawrence, Nathan P. Metzger, Corine P. Richard, Eric D. Berglund, Jeffrey M. Zigman
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Endocrinology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.146983

Internet

https://doi.org/10.1172/jci.insight.146983

Similar Items