Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

Mitochondria play a central role in metabolic homeostasis, and dysfunction of this organelle underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with alternating cationic and aromatic residues such as SS-31 (elamipretide) show promise as therapeutic compounds for mitoc...

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Bibliographic Details
Main Authors: Wayne Mitchell, Jeffrey D Tamucci, Emery L Ng, Shaoyi Liu, Alexander V Birk, Hazel H Szeto, Eric R May, Andrei T Alexandrescu, Nathan N Alder
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
mitochondria
peptide therapeutics
membrane interactions
NMR structure
structure-activity relationship
cardiolipin
Online Access:https://elifesciences.org/articles/75531

Internet

https://elifesciences.org/articles/75531

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