Synergistic Effect of a Combination of Proteasome and Ribonucleotide Reductase Inhibitors in a Biochemical Model of the Yeast <i>Saccharomyces cerevisiae</i> and a Glioblastoma Cell Line

Synergistic Effect of a Combination of Proteasome and Ribonucleotide Reductase Inhibitors in a Biochemical Model of the Yeast <i>Saccharomyces cerevisiae</i> and a Glioblastoma Cell Line

Proteasome inhibitors are used in the therapy of several cancers, and clinical trials are underway for their use in the treatment of glioblastoma (GBM). However, GBM becomes resistant to chemotherapy relatively rapidly. Recently, the overexpression of ribonucleotide reductase (RNR) genes was found t...

Full description

Bibliographic Details
Main Authors: Kirill A. Kulagin, Elizaveta S. Starodubova, Pamila J. Osipova, Anastasia V. Lipatova, Igor A. Cherdantsev, Svetlana V. Poddubko, Vadim L. Karpov, Dmitry S. Karpov
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Saccharomyces cerevisiae</i>
glioblastoma cell line
proteasome
ribonucleotide reductase
bortezomib
hydroxyurea
Online Access:https://www.mdpi.com/1422-0067/25/7/3977

Internet

https://www.mdpi.com/1422-0067/25/7/3977

Similar Items