High-resolution description of antibody heavy-chain repertoires in humans.

High-resolution description of antibody heavy-chain repertoires in humans.

Antibodies' protective, pathological, and therapeutic properties result from their considerable diversity. This diversity is almost limitless in potential, but actual diversity is still poorly understood. Here we use deep sequencing to characterize the diversity of the heavy-chain CDR3 region,...

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Bibliographic Details
Main Authors: Ramy Arnaout, William Lee, Patrick Cahill, Tracey Honan, Todd Sparrow, Michael Weiand, Chad Nusbaum, Klaus Rajewsky, Sergei B Koralov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3150326?pdf=render

Internet

http://europepmc.org/articles/PMC3150326?pdf=render

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