Belimumab Decreases Autophagy and Citrullination in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Belimumab Decreases Autophagy and Citrullination in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

Belimumab (BLM) is a B lymphocyte stimulator (BLyS) inhibitor approved for the treatment of systemic lupus erythematosus (SLE). Autophagy is a cell survival mechanism involved in the pathogenesis of SLE. Citrullination is a post-translational modification catalyzed by peptidylarginine deiminase (PAD...

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Bibliographic Details
Main Authors: Tania Colasanti, Francesca Romana Spinelli, Cristiana Barbati, Fulvia Ceccarelli, Susanna Scarpa, Marta Vomero, Cristiano Alessandri, Guido Valesini, Fabrizio Conti
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
belimumab
autophagy
citrullination
peptidylarginine deiminases (PADs)
systemic lupus erythematosus
IL-18
Online Access:https://www.mdpi.com/2073-4409/11/2/262

Internet

https://www.mdpi.com/2073-4409/11/2/262

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