Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones
Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been inves...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/7/6116/ |
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| author | Olga Igglessi-Markopoulou John Markopoulos Dimitris Matiadis Christos S. Karaiskos |
| author_facet | Olga Igglessi-Markopoulou John Markopoulos Dimitris Matiadis Christos S. Karaiskos |
| author_sort | Olga Igglessi-Markopoulou |
| collection | DOAJ |
| description | Catalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data. |
| first_indexed | 2024-04-12T16:59:33Z |
| format | Article |
| id | doaj.art-36662e33e0f24099becb6a26055406fa |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T16:59:33Z |
| publishDate | 2011-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-36662e33e0f24099becb6a26055406fa2022-12-22T03:24:06ZengMDPI AGMolecules1420-30492011-07-011676116612810.3390/molecules16076116Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-dionesOlga Igglessi-MarkopoulouJohn MarkopoulosDimitris MatiadisChristos S. KaraiskosCatalytic hydrogenation of 3,5-bis-arylidenetetramic acids, known for their biological activity, has been developed. The chemoselective ruthenium-catalyzed reduction of the exocyclic carbon-carbon double bonds on pyrrolidine-2,4-dione ring system, containing other reducible functions, has been investigated. Depending on the substrate the yield of the hydrogenation process can reach up to 95%. The structural elucidation has been established using NMR and HRMS spectral data.http://www.mdpi.com/1420-3049/16/7/6116/hydrogenationhomogeneous catalysisruthenium catalystsBINAParylidenetetramic acid |
| spellingShingle | Olga Igglessi-Markopoulou John Markopoulos Dimitris Matiadis Christos S. Karaiskos Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones Molecules hydrogenation homogeneous catalysis ruthenium catalysts BINAP arylidenetetramic acid |
| title | Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones |
| title_full | Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones |
| title_fullStr | Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones |
| title_full_unstemmed | Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones |
| title_short | Ruthenium-Catalyzed Selective Hydrogenation of bis-Arylidene Tetramic Acids. Application to the Synthesis of Novel Structurally Diverse Pyrrolidine-2,4-diones |
| title_sort | ruthenium catalyzed selective hydrogenation of bis arylidene tetramic acids application to the synthesis of novel structurally diverse pyrrolidine 2 4 diones |
| topic | hydrogenation homogeneous catalysis ruthenium catalysts BINAP arylidenetetramic acid |
| url | http://www.mdpi.com/1420-3049/16/7/6116/ |
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