A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants

A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants

Abstract Background The high-activity adenine base editors (ABEs), engineered with the recently-developed tRNA adenosine deaminases (TadA8e and TadA9), show robust base editing activity but raise concerns about off-target effects. Results In this study, we perform a comprehensive evaluation of ABE8e...

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Bibliographic Details
Main Authors: Shaofang Li, Lang Liu, Wenxian Sun, Xueping Zhou, Huanbin Zhou
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Genome Biology
Subjects:
Adenine base editor
TadA variants
Single nucleotide variant
T-DNA insertion
Off-target
Oryza sativa L
Online Access:https://doi.org/10.1186/s13059-022-02618-w

Internet

https://doi.org/10.1186/s13059-022-02618-w

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