Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens.

Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens.

BACKGROUND:Relevant preclinical models that recapitulate the key features of human pancreatic ductal adenocarcinoma (PDAC) are needed in order to provide biologically tractable models to probe disease progression and therapeutic responses and ultimately improve patient outcomes for this disease. Her...

Full description

Bibliographic Details
Main Authors: Dustin M Walters, Jayme B Stokes, Sara J Adair, Edward B Stelow, Cheryl A Borgman, Bryce T Lowrey, Wenjun Xin, Edik M Blais, Jae K Lee, Jason A Papin, J Thomas Parsons, Todd W Bauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3799939?pdf=render

Internet

http://europepmc.org/articles/PMC3799939?pdf=render

Similar Items