The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages

Abstract The discovery of STING-related innate immunity has recently provided a deep mechanistic understanding of immunopathy. While the detrimental effects of STING during sepsis had been well documented, the exact mechanism by which STING causes lethal sepsis remains obscure. Through single-cell R...

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Bibliographic Details
Main Authors: Jie Wu, Qinjie Liu, Xufei Zhang, Miaomiao Tan, Xuanheng Li, Peizhao Liu, Lei Wu, Fan Jiao, Zhaoyu Lin, Xiuwen Wu, Xin Wang, Yun Zhao, Jianan Ren
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05115-x

Internet

https://doi.org/10.1038/s41419-022-05115-x

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