EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells

EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells

IntroductionBeta cell dysfunction by loss of beta cell identity, dedifferentiation, and the presence of polyhormonal cells are main characteristics of diabetes. The straightforward strategy for curing diabetes implies reestablishment of pancreatic beta cell function by beta cell replacement therapy....

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Main Authors: Marija Đorđević, Peter Stepper, Clarissa Feuerstein-Akgoz, Clarissa Gerhauser, Verica Paunović, Anja Tolić, Jovana Rajić, Svetlana Dinić, Aleksandra Uskoković, Nevena Grdović, Mirjana Mihailović, Renata Z. Jurkowska, Tomasz P. Jurkowski, Jelena Arambašić Jovanović, Melita Vidaković
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
Arx gene
CRISPR/dCas9
diabetes
pancreatic alpha cells
epigenetic editing
targeted DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1134478/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1134478/full

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