RSK3 switches cell fate: from stress-induced senescence to malignant progression

RSK3 switches cell fate: from stress-induced senescence to malignant progression

Abstract Background TGFβ induces several cell phenotypes including senescence, a stable cell cycle arrest accompanied by a secretory program, and epithelial-mesenchymal transition (EMT) in normal epithelial cells. During carcinogenesis cells lose the ability to undergo senescence in response to TGFβ...

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Bibliographic Details
Main Authors: Anda Huna, Jean-Michel Flaman, Catalina Lodillinsky, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cellular senescence
Epithelial-mesenchymal transition
TGFβ
Breast tumor
Online Access:https://doi.org/10.1186/s13046-023-02909-5

Internet

https://doi.org/10.1186/s13046-023-02909-5

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