Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells.

Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells.

Dendritic cells (DC) have the potential to control the outcome of autoimmunity by modulating the immune response. In this study, we tested the ability of Fasciola hepatica total extract (TE) to induce tolerogenic properties in CpG-ODN (CpG) maturated DC, to then evaluate the therapeutic potential of...

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Bibliographic Details
Main Authors: Franco Carranza, Cristian Roberto Falcón, Nicolás Nuñez, Carolina Knubel, Silvia Graciela Correa, Ismael Bianco, Mariana Maccioni, Ricardo Fretes, María Fernanda Triquell, Claudia Cristina Motrán, Laura Cervi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3405066?pdf=render

Internet

http://europepmc.org/articles/PMC3405066?pdf=render

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