T160‐phosphorylated CDK2 defines threshold for HGF‐dependent proliferation in primary hepatocytes

T160‐phosphorylated CDK2 defines threshold for HGF‐dependent proliferation in primary hepatocytes

Abstract Liver regeneration is a tightly controlled process mainly achieved by proliferation of usually quiescent hepatocytes. The specific molecular mechanisms ensuring cell division only in response to proliferative signals such as hepatocyte growth factor (HGF) are not fully understood. Here, we...

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Bibliographic Details
Main Authors: Stephanie Mueller, Jérémy Huard, Katharina Waldow, Xiaoyun Huang, Lorenza A D'Alessandro, Sebastian Bohl, Kathleen Börner, Dirk Grimm, Steffen Klamt, Ursula Klingmüller, Marcel Schilling
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:Molecular Systems Biology
Subjects:
G1/S transition
hepatocyte proliferation
HGF
mathematical model
threshold
Online Access:https://doi.org/10.15252/msb.20156032

Internet

https://doi.org/10.15252/msb.20156032

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