Identification of drug candidates targeting monocyte reprogramming in people living with HIV

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

IntroductionPeople living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility of omics technologies for application to larger cohorts, we compared multiple omics data layers....

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Main Authors: Rainer Knoll, Lorenzo Bonaguro, Jéssica C. dos Santos, Stefanie Warnat-Herresthal, Maartje C. P. Jacobs-Cleophas, Edda Blümel, Nico Reusch, Arik Horne, Miriam Herbert, Melanie Nuesch-Germano, Twan Otten, Wouter A. van der Heijden, Lisa van de Wijer, Alex K. Shalek, Kristian Händler, Matthias Becker, Marc D. Beyer, Mihai G. Netea, Leo A. B. Joosten, Andre J. A. M. van der Ven, Joachim L. Schultze, Anna C. Aschenbrenner
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
systems immunology
transcriptomics
HIV
monocytes
inflammation
drug repurposing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275136/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275136/full

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