From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin

From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin

PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new antiseizure compounds, the 2,5-diketopiperazine halimide and i...

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Bibliographic Details
Main Authors: Daniëlle Copmans, Sara Kildgaard, Emma Roux, Michèle Partoens, Gert Steurs, Xinhui Wang, Wim M. De Borggraeve, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
marine natural products
drug discovery
epilepsy
zebrafish
plinabulin
halimide
Online Access:https://www.mdpi.com/1424-8247/15/2/247

Internet

https://www.mdpi.com/1424-8247/15/2/247

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