Cancer evolution is associated with pervasive positive selection on globally expressed genes.

Cancer is an evolutionary process in which cells acquire new transformative, proliferative and metastatic capabilities. A full understanding of cancer requires learning the dynamics of the cancer evolutionary process. We present here a large-scale analysis of the dynamics of this evolutionary proces...

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Bibliographic Details
Main Authors: Sheli L Ostrow, Ruth Barshir, James DeGregori, Esti Yeger-Lotem, Ruth Hershberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3945297?pdf=render