Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe

Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe

The S. pombe checkpoint kinase, Cds1, protects the integrity of stalled DNA replication forks after its phosphorylation at threonine-11 by Rad3 (ATR). Modified Cds1 associates through its N-terminal forkhead-associated domain (FHA)-domain with Mrc1 (Claspin) at stalled forks. We report here that nut...

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Bibliographic Details
Main Authors: Jessica Fletcher, Liam Griffiths, Thomas Caspari
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Cells
Subjects:
replication
kinase
checkpoint
postmitotic
fission yeast
S. pombe
Cds1
starvation
glucose
nitrogen
cell cycle
Online Access:http://www.mdpi.com/2073-4409/7/2/15

Internet

http://www.mdpi.com/2073-4409/7/2/15

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