Fus1 KO mouse as a model of oxidative stress-mediated sporadic Alzheimer’s disease: circadian disruption and long-term spatial and olfactory memory impairments.

Fus1 KO mouse as a model of oxidative stress-mediated sporadic Alzheimer’s disease: circadian disruption and long-term spatial and olfactory memory impairments.

Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD) to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and...

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Bibliographic Details
Main Authors: Guillermo Coronas-Samano, Keeley L. Baker, Winston J. T. Tan, Alla V. Ivanova, Justus V Verhagen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Free Radicals
Hippocampus
Inflammation
Olfactory Bulb
Oxidative Stress
Sleep
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00268/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00268/full

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