Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

Autophagy is a cellular process that degrades cytoplasmic cargo by engulfing it in a double-membrane vesicle, known as the autophagosome, and delivering it to the lysosome. The ATG12–5–16L1 complex is responsible for conjugating members of the ubiquitin-like ATG8 protein family to phosphatidylethano...

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Bibliographic Details
Main Authors: Lisa M Strong, Chunmei Chang, Julia F Riley, C Alexander Boecker, Thomas G Flower, Cosmo Z Buffalo, Xuefeng Ren, Andrea KH Stavoe, Erika LF Holzbaur, James H Hurley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
autophagy
mitophagy
parkinson's disease
x-ray crystallography
vesicle reconstitution
LC3
Online Access:https://elifesciences.org/articles/70372

Internet

https://elifesciences.org/articles/70372

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