Genome rearrangements in Escherichia coli during de novo acquisition of resistance to a single antibiotic or two antibiotics successively

Genome rearrangements in Escherichia coli during de novo acquisition of resistance to a single antibiotic or two antibiotics successively

Abstract Background The ability of bacteria to acquire resistance to antibiotics relies to a large extent on their capacity for genome modification. Prokaryotic genomes are highly plastic and can utilize horizontal gene transfer, point mutations, and gene deletions or amplifications to realize genom...

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Bibliographic Details
Main Authors: Marloes Hoeksema, Martijs J. Jonker, Keshia Bel, Stanley Brul, Benno H. ter Kuile
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Genomics
Subjects:
Genome rearrangement
de novo resistance
Gene amplification
Prophage
Online Access:http://link.springer.com/article/10.1186/s12864-018-5353-y

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http://link.springer.com/article/10.1186/s12864-018-5353-y

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