Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Abstract Cyclic GMP-AMP synthase (cGAS) is an essential sensor of aberrant cytosolic DNA for initiating innate immunity upon invading pathogens and cellular stress, which is considered as a potential drug target for autoimmune and autoinflammatory diseases. Here, we report the discovery of a class o...

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Bibliographic Details
Main Authors: Xiaoquan Wang, Youqiao Wang, Anqi Cao, Qinhong Luo, Daoyuan Chen, Weiqi Zhao, Jun Xu, Qinkai Li, Xianzhang Bu, Junmin Quan
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41892-5

Internet

https://doi.org/10.1038/s41467-023-41892-5

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