Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms

Here, the authors perform large-scale high-resolution Parkinson’s disease metagenomics analyses, revealing widespread dysbiosis characterized by overabundance of pathogens, immunogens, toxicants, and curli, reduction in neuroprotective and antiinflammatory molecules, and dysregulated neuroactive sig...

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Bibliographic Details
Main Authors: Zachary D. Wallen, Ayse Demirkan, Guy Twa, Gwendolyn Cohen, Marissa N. Dean, David G. Standaert, Timothy R. Sampson, Haydeh Payami
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34667-x