Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway

Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited. Suramin is used to treat African sleeping sickness. This study aimed to investigate the pharmac...

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Bibliographic Details
Main Authors: Zi-Miao Liu, Cheng-Chang Lu, Po-Chih Shen, Shih-Hsiang Chou, Chia-Lung Shih, Jian-Chih Chen, Yin Chun Tien
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2021-08-01
Series:Bone & Joint Research
Subjects:
suramin
intervertebral disc degeneration
nf-κb
apoptosis
inflammation
western blotting
cytokines
il-8
aggrecan
mmp-13
matrix metalloproteinases-3
adamts-5
adamts-4
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2020-0041.R3

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2020-0041.R3

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