A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens

A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens

The global threat of multidrug-resistant Gram-negative bacterial pathogens necessitates the development of new and effective antibiotics. FtsZ is an essential and highly conserved cytoskeletal protein that is an appealing antibacterial target for new antimicrobial therapeutics. However, the effectiv...

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Bibliographic Details
Main Authors: Eric J. Bryan, Qi Qiao, Yuxuan Wang, Jacques Y. Roberge, Edmond J. LaVoie, Daniel S. Pilch
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antibiotics
Subjects:
<i>Klebsiella pneumoniae</i>
<i>Acinetobacter baumannii</i>
antibiotic-siderophore conjugate
antibiotic uptake
FtsZ inhibitor-antibiotic synergy
Online Access:https://www.mdpi.com/2079-6382/13/3/209

Internet

https://www.mdpi.com/2079-6382/13/3/209

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