CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection.

CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection.

HIV-1 frequently escapes from CD8 T cell responses via HLA-I restricted adaptation, leading to the accumulation of adapted epitopes (AE). We previously demonstrated that AE compromise CD8 T cell responses during acute infection and are associated with poor clinical outcomes. Here, we examined the im...

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Bibliographic Details
Main Authors: Kai Qin, Sushma Boppana, Victor Y Du, Jonathan M Carlson, Ling Yue, Dario A Dilernia, Eric Hunter, Robbie B Mailliard, Simon A Mallal, Anju Bansal, Paul A Goepfert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007970

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https://doi.org/10.1371/journal.ppat.1007970

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