Littermate-Controlled Experiments Reveal Eosinophils Are Not Essential for Maintaining Steady-State IgA and Demonstrate the Influence of Rearing Conditions on Antibody Phenotypes in Eosinophil-Deficient Mice

Littermate-Controlled Experiments Reveal Eosinophils Are Not Essential for Maintaining Steady-State IgA and Demonstrate the Influence of Rearing Conditions on Antibody Phenotypes in Eosinophil-Deficient Mice

Conflicting data has emerged regarding a role for eosinophils in IgA production, with some reports that eosinophils support both secretory and circulating IgA levels during homeostasis. Previous studies have compared antibody levels between wildtype and eosinophil-deficient mice, but these mice were...

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Bibliographic Details
Main Authors: Rachael D. FitzPatrick, Mia H. E. Kennedy, Katherine M. Lawrence, Courtney M. Gauthier, Brandon E. Moeller, Andrew N. Robinson, Lisa A. Reynolds
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
eosinophils
secretory IgA
circulating IgA
antibodies
co-rearing
co-housing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.557960/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.557960/full

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