Assessing the Inhibitory Potential of Kinase Inhibitors In Vitro: Major Pitfalls and Suggestions for Improving Comparability of Data Using CK1 Inhibitors as an Example

Assessing the Inhibitory Potential of Kinase Inhibitors In Vitro: Major Pitfalls and Suggestions for Improving Comparability of Data Using CK1 Inhibitors as an Example

Phosphorylation events catalyzed by protein kinases represent one of the most prevalent as well as important regulatory posttranslational modifications, and dysregulation of protein kinases is associated with the pathogenesis of different diseases. Therefore, interest in developing potent small mole...

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Bibliographic Details
Main Authors: Aileen Roth, Adrian Gihring, Florian Göser, Christian Peifer, Uwe Knippschild, Joachim Bischof
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
protein kinase
small molecule inhibitor
IC<sub>50</sub>
inhibitor constant
K<sub>i</sub>
workflow
Online Access:https://www.mdpi.com/1420-3049/26/16/4898

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https://www.mdpi.com/1420-3049/26/16/4898

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