Development and Validation of [<sup>3</sup>H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs

Development and Validation of [<sup>3</sup>H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs

GluN2B-enriched <i>N</i>-methyl-<span style="font-variant: small-caps;">D</span>-aspartate receptors (NMDARs) are implicated in several neurodegenerative and psychiatric diseases, such as Alzheimer’s disease. No clinically valid GluN1/2B therapeutic exists due to a...

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Bibliographic Details
Main Authors: Hazem Ahmed, Livio Gisler, Nehal H. Elghazawy, Claudia Keller, Wolfgang Sippl, Steven H. Liang, Ahmed Haider, Simon M. Ametamey
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
GluN1/2B receptors
NMDA
[<sup>3</sup>H]ifenprodil
σ1 and σ2 receptors
receptor occupancy
PET imaging
Online Access:https://www.mdpi.com/1424-8247/15/8/960

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https://www.mdpi.com/1424-8247/15/8/960

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