Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance

Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance

Functional loss of myosin Vb (MYO5B) induces a variety of deficits in intestinal epithelial cell function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID). The impact of MYO5B loss on differentiated cell lineage choice has not been investigated. We quantified the popu...

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Bibliographic Details
Main Authors: Izumi Kaji, Joseph T. Roland, Sudiksha Rathan-Kumar, Amy C. Engevik, Andreanna Burman, Anna E. Goldstein, Masahiko Watanabe, James R. Goldenring
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-08-01
Series:JCI Insight
Subjects:
Gastroenterology
Online Access:https://doi.org/10.1172/jci.insight.150416

Internet

https://doi.org/10.1172/jci.insight.150416

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