Combined – whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment

Combined – whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment

BackgroundAn interplay between immune cells and resident skin and joint stromal cells is implicated in psoriatic arthritis (PsA), yet the mechanisms remain elusive with a paucity of molecular biomarkers for activity and response. Combined transcriptomic and immunophenotypic analysis of whole blood a...

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Bibliographic Details
Main Authors: Alexandros Grivas, Maria Grigoriou, Nikos Malissovas, George Sentis, Anastasia Filia, Sofia Flouda, Pelagia Katsimpri, Panayotis Verginis, Dimitrios T. Boumpas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Psoriatic arthritis
transcriptome
molecular signatures
skin fibroblast
response to treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.964274/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.964274/full

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