Gastric pH in Rats: Key Determinant for Preclinical Evaluation of pH-dependent Oral Drug Absorption

Gastric pH in Rats: Key Determinant for Preclinical Evaluation of pH-dependent Oral Drug Absorption

Data on gastric pH in rats to be used in preclinical models for pH-dependent drug absorption are still limited or contradictory. The aim of this study was to describe gastric pH in rats at fasted state and to evaluate its changes induced by pentagastrin or omeprazole in order to mimic gastric pH at...

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Bibliographic Details
Main Authors: Martin Šíma, Nikolina Kutinová-Canová, Pavel Ryšánek, Jana Hořínková, Denisa Moškořová, Ondřej Slanař
Format: Article
Language:English
Published: Karolinum Press 2019-01-01
Series:Prague Medical Report
Subjects:
Gastric pH
Rats
Oral drug absorption
Omeprazole
Pentagastrin
Online Access:https://pmr.lf1.cuni.cz/120/1/0005/

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