DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function

Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex. How DNA strands are chosen and selectively passed to yield appropriate topological outcomes – for example, decatenation vs. ca...

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Bibliographic Details
Main Authors: Joshua Jeong, Joyce H Lee, Claudia C Carcamo, Matthew W Parker, James M Berger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
liquid-liquid phase separation
topoisomerase
DNA knots
catenanes
DNA topology
Online Access:https://elifesciences.org/articles/81786

Internet

https://elifesciences.org/articles/81786

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