Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide
As opposed to small molecules, macrocyclic peptides possess a large surface area and are recognised as promising candidates to selectively treat diseases by disrupting specific protein−protein interactions (PPIs). Due to the difficulty in predicting cyclopeptide conformations in solution,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/4/922 |