Identification of Anti-Tuberculosis Drugs Targeting DNA Gyrase A and Serine/Threonine Protein Kinase PknB: A Machine Learning-Assisted Drug-Repurposing Approach

Identification of Anti-Tuberculosis Drugs Targeting DNA Gyrase A and Serine/Threonine Protein Kinase PknB: A Machine Learning-Assisted Drug-Repurposing Approach

Tuberculosis (TB) is a global health challenge associated with considerable levels of illness and mortality worldwide. The development of innovative therapeutic strategies is crucial to combat the rise of drug-resistant TB strains. DNA Gyrase A (GyrA) and serine/threonine protein kinase (PknB) are p...

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Bibliographic Details
Main Authors: Dongwoo Lee, Md Ataul Islam, Sathishkumar Natarajan, Dawood Babu Dudekula, Hoyong Chung, Junhyung Park, Bermseok Oh
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Tropical Medicine and Infectious Disease
Subjects:
tuberculosis
DNA Gyrase A
PknB
drug-repurposing
molecular docking
machine learning
Online Access:https://www.mdpi.com/2414-6366/9/12/288

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https://www.mdpi.com/2414-6366/9/12/288

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