Validation and tuning of in situ transcriptomics image processing workflows with crowdsourced annotations.

Recent advancements in in situ methods, such as multiplexed in situ RNA hybridization and in situ RNA sequencing, have deepened our understanding of the way biological processes are spatially organized in tissues. Automated image processing and spot-calling algorithms for analyzing in situ transcrip...

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Bibliographic Details
Main Authors: Jenny M Vo-Phamhi, Kevin A Yamauchi, Rafael Gómez-Sjöberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1009274