Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts

Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts

Abstract Background The purpose of this study was to determine the role of Orai1 in the regulation of the proliferation and cell cycle of osteoblasts. Methods The expression of Orai1 was inhibited by Orai1 small interfering RNA (siRNA) in MC3T3-E1 cells. Following Orai1 downregulation, cell prolifer...

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Bibliographic Details
Main Authors: Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Orai1
Ras
NF-κB
Cyclin D1
Proliferation
Osteoblasts
Online Access:https://doi.org/10.1186/s12891-022-05311-y

Internet

https://doi.org/10.1186/s12891-022-05311-y

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