Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells
This study investigates how binding/unbinding kinetics of a benzimidazole-derivative DNA inhibitor in E. coli cells depends on cell growth and physiology and demonstrates the effect of this coupling on drug efficacy.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04604-9 |