Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells
This study investigates how binding/unbinding kinetics of a benzimidazole-derivative DNA inhibitor in E. coli cells depends on cell growth and physiology and demonstrates the effect of this coupling on drug efficacy.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04604-9 |
| _version_ | 1797863794354946048 |
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| author | Dai Le Tatsuya Akiyama David Weiss Minsu Kim |
| author_facet | Dai Le Tatsuya Akiyama David Weiss Minsu Kim |
| author_sort | Dai Le |
| collection | DOAJ |
| description | This study investigates how binding/unbinding kinetics of a benzimidazole-derivative DNA inhibitor in E. coli cells depends on cell growth and physiology and demonstrates the effect of this coupling on drug efficacy. |
| first_indexed | 2024-04-09T22:42:25Z |
| format | Article |
| id | doaj.art-36c37c98fdca416f9549d704ee7452e1 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-09T22:42:25Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-36c37c98fdca416f9549d704ee7452e12023-03-22T12:04:54ZengNature PortfolioCommunications Biology2399-36422023-02-01611710.1038/s42003-023-04604-9Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cellsDai Le0Tatsuya Akiyama1David Weiss2Minsu Kim3Department of Physics, Emory UniversityDepartment of Physics, Emory UniversityGraduate Division of Biological and Biomedical Sciences, Emory UniversityDepartment of Physics, Emory UniversityThis study investigates how binding/unbinding kinetics of a benzimidazole-derivative DNA inhibitor in E. coli cells depends on cell growth and physiology and demonstrates the effect of this coupling on drug efficacy.https://doi.org/10.1038/s42003-023-04604-9 |
| spellingShingle | Dai Le Tatsuya Akiyama David Weiss Minsu Kim Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells Communications Biology |
| title | Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells |
| title_full | Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells |
| title_fullStr | Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells |
| title_full_unstemmed | Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells |
| title_short | Dissociation kinetics of small-molecule inhibitors in Escherichia coli is coupled to physiological state of cells |
| title_sort | dissociation kinetics of small molecule inhibitors in escherichia coli is coupled to physiological state of cells |
| url | https://doi.org/10.1038/s42003-023-04604-9 |
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