Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice

Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice

Abstract Background Intestinal epithelial cell (IEC) mitochondrial dysfunction involvement in inflammatory bowel diseases (IBD), including Crohn’s disease affecting the small intestine, is emerging in recent studies. As the interface between the self and the gut microbiota, IECs serve as hubs of bid...

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Bibliographic Details
Main Authors: Kibrom M. Alula, Alexander S. Dowdell, Brittany LeBere, J. Scott Lee, Cassandra L. Levens, Kristine A. Kuhn, Benny A. Kaipparettu, Winston E. Thompson, Richard S. Blumberg, Sean P. Colgan, Arianne L. Theiss
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Microbiome
Subjects:
Inflammatory bowel disease
Crohn’s disease
Short-chain fatty acids
Butyrate
Enteroids
Mitochondria
Online Access:https://doi.org/10.1186/s40168-023-01686-9

Internet

https://doi.org/10.1186/s40168-023-01686-9

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