Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase

Manumycin A is postulated to be a specific inhibitor against the farnesyltransferase (FTase) since this effect has been shown in 1993 for yeast FTase. Since then, plenty of studies investigated Manumycin A in human cells as well as in model organisms like Caenorhabditis elegans. Some studies pointed...

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Bibliographic Details
Main Authors: Anna Hagemann, Philipp Klemens Altrogge, Miriam Caroline Alice Kehrenberg, Daniel Diehl, Dominik Jung, Lea Weber, Hagen Sjard Bachmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Chemistry
Subjects:
farnesyltransferase
Manumycin A
apoptosis
prenylation
Caenorhabditis elegans
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.967947/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.967947/full

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