Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb.

Recent studies on the large Maf transcription factors have shown that Mafb and Mafa have respective and distinctive roles in β-cell development and maturation. However, whether this difference in roles is due to the timing of the gene expression (roughly, expression of Mafb before birth and of Mafa...

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Bibliographic Details
Main Authors: Haruka Nagasaki, Tokio Katsumata, Hisashi Oishi, Pei-Han Tai, Yukari Sekiguchi, Ryusuke Koshida, Yunshin Jung, Takashi Kudo, Satoru Takahashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4232560?pdf=render