Engineering a switchable single‐chain TEV protease to control protein maturation in living neurons

Engineering a switchable single‐chain TEV protease to control protein maturation in living neurons

Abstract Engineered proteases are promising tools to address physiological and pathophysiological questions as well as to develop new therapeutic approaches. Here we introduce a new genetically encoded engineered single‐chain tobacco etch virus protease, allowing to control proprotein cleavage in di...

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Bibliographic Details
Main Authors: Pietro Renna, Cristian Ripoli, Onur Dagliyan, Francesco Pastore, Marco Rinaudo, Agnese Re, Fabiola Paciello, Claudio Grassi
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Bioengineering & Translational Medicine
Subjects:
dendritic spines
neuronal plasticity
neurotrophins
protease
protein engineering
TEV
Online Access:https://doi.org/10.1002/btm2.10292

Internet

https://doi.org/10.1002/btm2.10292

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